A behavioral tool for screening antidepressant drugs and neurochemical mechanisms
β Scribed by Lewis S. Seiden
- Book ID
- 113226284
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 107 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0091-3057
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Oneβdimensional NMR spectroscopy has proven to be a powerful technique for screening compound libraries in drug discovery. We report a novel water ligandβobserved gradient spectroscopy (WaterLOGSY) pulse sequence, named Aroma WaterLOGSY, that selectively detects aromatic WaterLOGSY sign
Those antidepressant drugs that are in wide clinical use decrease response rate and increase reinforcement rate when administered to rats performing on a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule. Drugs that are not antidepressants do not have this effect. In this experiment, t