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A BDNF autocrine loop in adult sensory neurons prevents cell death

✍ Scribed by Acheson, Ann; Conover, Joanne C.; Fandl, James P.; DeChiara, Thomas M.; Russell, Michelle; Thadani, Anu; Squinto, Stephen P.; Yancopoulos, George D.; Lindsay, Ronald M.


Book ID
109791572
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
471 KB
Volume
374
Category
Article
ISSN
0028-0836

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In the present investigation, we studied whether neurotrophin-3 (NT-3) contributes to the rescue of axotomized Clarke's nucleus (CN) neurons in adult rats. A significant (24%) loss of CN neurons occurred at L-1 ipsilateral to T-8 hemisection by 14 days, which reached 31% at 2 months and then stabili