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A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia

✍ Scribed by Gabriella Cirmena; Stefania Aliano; Giuseppina Fugazza; Roberto Bruzzone; Anna Garuti; Renata Bocciardi; Andrea Bacigalupo; Roberto Ravazzolo; Alberto Ballestrero; Mario Sessarego


Book ID
113513331
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
383 KB
Volume
183
Category
Article
ISSN
0165-4608

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## Abstract Chronic myeloid leukemia (CML) is characterized by the presence of a t(9;22)(q34;q11.2), which leads to the well‐known BCR–ABL1 fusion protein. We describe a patient who was diagnosed clinically with a typical CML but on cytogenetic analysis was found to have a t(9;22)(p24;q11.2). Chrom

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## Abstract Activating mutations in __JAK2__ are found in virtually all patients with polycythemia vera, and about half of those with essential thrombocythemia and primary myelofibrosis. In addition, less common aberrations (particularly gene fusions) involving __JAK2__ have been described in acute