Twenty patients with advanced squamous cell carcinomas (SCC) of the head and neck were entered into a phase II study of mitoxantrone at a dosage of either 12 mg/m2 or 14 mg/m2 given at 3 weekly intervals. None of the patients had received prior chemotherapy. One patient had a partial remission. Two
A Bayesian hierarchical model for DCE-MRI to evaluate treatment response in a phase II study in advanced squamous cell carcinoma of the head and neck
โ Scribed by Brandon Whitcher; Volker J. Schmid; David J. Collins; Matthew R. Orton; Dow-Mu Koh; Isabela Diaz de Corcuera; Marta Parera; Josep M. del Campo; Nandita M. deSouza; Martin O. Leach; Kevin Harrington; Iman A. El-Hariry
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 633 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0968-5243
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Twenty patients with squamous cell carcinoma of the head and neck (SCC H/N) were treated with Adriamycin (doxorubicin) at a dosage of 60 mg/m\* at 3-week intervals. No patient had received surgery, radiation, or chemotherapy before treatment with Adriamycin. Responses were observed in 44% of 18 eval
## Background: The anti-cancer gene, e1a, can be complexed to a lipid carrier, dc-cholesterol:dope, to form tgdcc-e1a, which can be injected directly into tumors. ## Methods: Twenty-four patients with recurrent, unresectable, head and neck cancer were treated with intratumoral injections of tgdcc