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A Bayesian Approach to Copy-Number–Polymorphism Analysis in Nuclear Pedigrees

✍ Scribed by Konstantina Kosta; Ian Sabroe; Jonathan Göke; Robert J. Nibbs; John Tsanakas; Moira K. Whyte; M. Dawn Teare

Book ID
117855246
Publisher
American Society of Human Genetics
Year
2007
Tongue
English
Weight
397 KB
Volume
81
Category
Article
ISSN
0002-9297

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We describe the application of a Markov Chain Monte Carlo approach for multipoint mapping of a quantitative trait locus to the Nuclear Families simulated data. The method involves repeated sampling of genotype vectors for each nuclear family from their conditional distributions, given phenotypes, ma