A Base-Catalyzed, Direct Synthesis of 3,5-Disubstituted 1,2,4-Triazoles from Nitriles and Hydrazides.
β Scribed by Kap-Sun Yeung; Michelle E. Farkas; John F. Kadow; Nicholas A. Meanwell
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 25 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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A number of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles have been prepared by the reaction of aromatic nitriles with hydrazine dihydrochloride or sulfate with an excess of hydrazine hydrate in ethylene or diethylene glycol under a nitrogen atmosphere. The structures of the new triazoles