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A-86929: A selective dopamine D1 receptor agonist with anti-Parkinsonian efficacy in MPTP-lesioned primate models

✍ Scribed by K. Shiosaki; P. Jenner; P. Bedard; C.W. Lin; D. Britton; B. Bianchi; R. Grondin; Y. Hong; M. Michaelides; T. Miller; L. Smith; M. Stashko; M. Williams

Book ID: 119179725
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 138 KB
Volume: 31
Category: Article
ISSN: 1043-6618
DOI: 10.1016/1043-6618(95)86692-2

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## Abstract Certain aminotetralins are known to be potent dopamine D~2~ receptor agonists. N‐0923, [‐]2‐(N‐propyl‐N‐2‐thienylethylamino)‐5‐hydroxytetralin HCl, recognizes the high and low affinity states of the D~2~ receptor in membranes from bovine caudate with a K~low~ of 79 nM. The selectivity r