## Abstract For Abstract see ChemInform Abstract in Full Text.
A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin.
✍ Scribed by M. Aghazade Tabrizi; P.G. Baraldi; M. Guarneri; S. Manfredini; G.P. Pollini; D. Simoni
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 227 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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## Abstract 3‐Alkyl/aryl‐3‐ureido‐1__H__,3__H__‐quinoline‐2,4‐diones (**2**) and 3a‐alkyl/aryl‐9b‐hydroxy‐3,3a,5,9b‐tetrahydro‐1__H__‐imidazo[4,5‐__c__]quinoline‐2,4‐diones (**3**) react in boiling concentrated HCl to give 5‐alkyl/aryl‐4‐(2‐aminophenyl)‐1,3‐dihydro‐2__H__‐imidazol‐2‐ones (**6**). T
Regio-and stereoselective 1,3-dipolar cycloaddition of nitrile oxide to optically active asilyl allyl alcohol provides a useful preparation of 3,4,5-trisubstituted 4,5-dihydroisoxazoles, which are readily converted into chiral 4-substituted 5,6-dihydro-4H-[ 1,2]-oxazines in 73-100% yields on treatme