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A 2D image-based approach for modelling some glycogen synthase kinase 3 inhibitors

✍ Scribed by Matheus P. Freitas


Book ID
105770857
Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
246 KB
Volume
16
Category
Article
ISSN
1054-2523

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A concise synthesis of 4,6-disubstituted pyrrolo[2,3-d]pyrimidines is described. The key step involves the formation of an ether or thioether linkage along with concurrent ring closure in one-pot to yield the desired product in only two steps from a common intermediate. The reaction is chemoselectiv