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A 1H and 31P NMR study of cis-Pt(NH3)2 [d(CpGpG)-N7 (2),N7 (3)] The influence of a 5′-terminal cytosine, on the structure of the cis-Pt(NH3)2 [d(GpG)-N7,N7] instrastrand cross-link : The influence of a 5′-terminal cytosine, on the structure of the cis-Pt(NH, [d(GpG)-N7,N7J intrastrand cross-link

✍ Scribed by Jeroen H. J. DEN HARTOG; Cornelis ALTONA; Gijs A. VANDER MAREL; Jan REEDIJK


Book ID
115122940
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
887 KB
Volume
147
Category
Article
ISSN
1432-1327

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In aqueous solution, bis(nucleoside) complexes formed by the reaction of cis-[Pt(NH3)2(H2O)2]2+ with an excess of either adenosine (ado) or a mixture of adenosine and guanosine (guo) undergo a slow N7--> N1 linkage isomerisation in the adenine moiety. The isomerisation probably involves the breaking