A 13C spin-lattice relaxation study of dipeptides containing glycine and proline: Mobility of the cyclic proline side chain
✍ Scribed by E. T. Fossel; K. R. K. Easwaran; E. R. Blout
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1975
- Tongue
- English
- Weight
- 453 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
Abstract
Molecular dynamics of the cyclic dipeptides cyclo(Gly‐L‐Pro), cyclo‐(L‐Pro‐L‐Pro), and cyclo(L‐Pro‐D‐Pro) and the linear dipeptides L‐Pro‐Gly and cis and trans Gly‐L‐Pro were studied in neutral aqueous solution by ^13^C nuclear magnetic resonance. Spinlattice relaxation times (T~1~) were determined for each individual carbon atom. The correlation times, τ, were derived from a semiquantitative analysis of the T~1~ data. The correlation times of the proline ring carbons, β, γ, and δ suggest that the cyclic dipeptides have more restriction of conformational freedom in the proline ring than the linear dipeptides. This effect is most pronounced on the γ carbon.