A 1-year time course study of the relaxation times and histology for irradiated rat lungs

✍ Scribed by Sumie Shioya; T Munetaka Haida; Minoru Fukuzaki; Yoshiaki Ono; Masayuki Tsuda; Yasuyo Ohta; Hajime Yamabayashi

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 615 KB
• Volume: 14
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910140220

✦ Synopsis

Abstract

To investigate the NMR relaxation times for irradiated rat lung tissue, we measured T~1~, and T~2~ at 11 different times during the injury's 1‐year time course. A biexponential analysis of T~2~ was used to determine T~2~ fast (T~2f~) and T~2~ slow (T~2s~). In addition, we measured water content and correlated changes in the relaxation times with pathological changes. The correlation indicates the following: (1) Shortly after irradiation, the biexponential T~2~ decay for 1/3 of the samples became monoexponential and there were no noticeable pathological changes observed using light microscopy. (2) During radiation pneumonitis, T~2f~ and T~2s~ were prolonged. This accompanied acute edematous changes and inflammatory cell infiltration. (3) Finally, during radiation fibrosis T~1~ shortened and collagen increased. We observed no significant correlation between relaxation time changes and water content changes throughout the 1‐year time course. © 1990 Academic Press, Inc.