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99mTc complexes of α,α-disubstituted, α-hydroxy carboxylic acids

✍ Scribed by Fabio Colombo; Mario Matarrese; Ferruccio Fazio; Edward Deutsch

Book ID
103922410
Publisher
Elsevier Science
Year
1990
Weight
553 KB
Volume
41
Category
Article
ISSN
0883-2889

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✦ Synopsis

99mTc complexes of 2-ethyl-2-hydrobutyric acid, 2-hydroxyisobutyric acid and (+)- and (-)-citramalic acid are readily prepared in high yield and high purity by reduction of 99mTcO4- in the presence of excess ligand. The resulting agents are very stable in vitro, but can undergo some decomposition during chromatographic analysis unless appropriate precautions are taken. Biodistribution studies in rats and dogs show that these new 99mTc agents accumulate primarily in the kidney and urinary bladder.

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Enantioselective synthesis of α-hydroxy
Enantioselective synthesis of α-hydroxy carboxylic acids: Direct conversion of α-oxocarboxylic acids to enantiomerically enriched α-hydroxy carboxylic acids via neighboring group control
✍ Zhe Wang; Brittany La; Joseph M. Fortunak; Xian-Jun Meng; George W. Kabalka 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 183 KB

o~-Oxocarboxylic acids can be reduced to the corresponding ~-hydroxy carboxylic acids employing DIP-CI ~ as a reducing agent. The cz-carboxylic substituent exerts a remarkable neighboring group effect on the reduction. The reaction presumably proceeds in an intramolecular fashion through a "'rigid"