993 - Exploiting hypoxia: Bioreductive drugs and gene therapy approache
β Scribed by Ian J. Stratford
- Book ID
- 117665235
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 222 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Tumor hypoxia has long been recognized as a critical issue in oncology. Resistance of hypoxic areas has been shown to affect treatment outcome after radiation, chemotherapy, and surgery in a number of tumor sites. Two main strategies to overcome tumor hypoxia are to increase the deliver
## Abstract ## Background We proposed to exploit hypoxiaβinducible factor (HIF)β1Ξ± overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIFβ1Ξ± to arrangements of hypoxia response elements.