99 BASELINE PREDICTIVE FACTORS OF URSODEOXYCHOLIC ACID RESPONSE IN PRIMARY BILIARY CIRRHOSIS
β Scribed by Carbone, M.; Mells, G.; Cordell, H.J.; Heneghan, M.A.; Neuberger, J.M.; Donaldson, P.T.; Bathgate, A.J.; Burroughs, A.K.; Davies, M.H.; Day, D.B.; Dawwas, M.F.; Thomson, S.; Alexander, G.J.; Jones, D.E.; Sandford, R.N.
- Book ID
- 123442930
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 475 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0168-8278
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Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, doubleblind, placebo-controlled trial of ursodeoxycholic acid (UDCA) (10-12 mg/kg/d) taken as a single bedtime dose. Specimens were analyzed
The aim of this study was to define factors predictive of the onset of the terminal phase, defined by hyperbilirubinemia or the occurrence of a severe clinical complication, in patients with primary biliary cirrhosis treated with ursodeoxycholic acid. The 97 primary biliary cirrhosis patients in thi