✦ LIBER ✦

971 SEMAPHORIN 3C PROMOTES SURVIVAL SIGNALING AND CASTRATION RESISTANT PROGRESSION IN PROSTATE CANCER

✍ Scribed by Hayashi, Norihiro; Shiota, Masaki; Kuruma, Hidetoshi; Egawa, Shin; Ong, Christopher; Gleave, Martin

Book ID: 118484722
Publisher: Lippincott Williams and Wilkins
Year: 2012
Tongue: English
Weight: 47 KB
Volume: 187
Category: Article
ISSN: 0022-5347
DOI: 10.1016/j.juro.2012.02.1070

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## Abstract ## BACKGROUND. Tissue inhibitor of metalloproteinase‐1 (TIMP‐1) has paradoxical multifunctional roles in tumorigenesis: inhibition of the catalytic activity of matrix metalloproteinases and apoptosis as well as promotion of angiogenesis and tumor growth. Elevated TIMP‐1 levels have bee