96/05484 Coal tar residues produce both DNA adducts and oxidative DNA damage in human mammary epithelial cells

Constitutive overexpression of CDC25A in

Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites

✍ Maria Giulia Cangi; Sara Piccinin; Lorenza Pecciarini; Anna Talarico; Elena Dal 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 637 KB

## Abstract CDC25A phosphatase, an essential component of the cell cycle machinery, is also a key player in integrating the specific signals of checkpoint control in response to DNA damage. There are several lines of evidence that indicate a role for CDC25A in cancer development, consistent with th