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96 Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia


Book ID
117638723
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
156 KB
Volume
15
Category
Article
ISSN
0939-4753

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✍ Marianne Abifadel; Jean-Pierre Rabès; Sélim Jambart; Georges Halaby; Marie-Hélèn 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 1 views

Autosomal dominant hypercholesterolemia (ADH), a major risk for coronary heart disease, is associated with mutations in the genes encoding the low-density lipoproteins receptor (LDLR), its ligand apolipoprotein B (APOB) or PCSK9 (Proprotein Convertase Subtilin Kexin 9). Familial hypercholesterolemia