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942 Epigenetic Silencing of DACH1 Induces the Invasion and Migration of Gastric Cancer by Activating TGF-β Signaling

✍ Scribed by Yan, Wenji; Wu, Kongming; Yang, Yunsheng; Guo, Mingzhou


Book ID
122227519
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
545 KB
Volume
146
Category
Article
ISSN
0016-5085

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TGF-beta strongly promotes local tumor progression in advanced epithelial tumors, though the underlying mechanisms are poorly understood. In the present study, we demonstrate the potential of TGF-beta to increase the invasiveness of the pancreatic cancer cell lines PANC-1 and IMIM-PC1. TGF-beta-indu