927 LOSS OF P63 (ΔNP63α) PROMOTES INVASION OF UROTHELIAL CARCINOMAS
✍ Scribed by F. Koaa; H. Fukushima; S. Kawakami; Y. Fujii; S. Yoshida; E. Ratovitski; B. Trink; K. Kihara
- Book ID
- 119621644
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 124 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1569-9056
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## Abstract p63 is a member of the p53 family and ΔNp63α is the dominant‐expressing isoform of p63 in basal layer of normal stratified epithelium and human squamous cell carcinoma (SCC) cells. We have previously reported that down‐regulation of p63 was accompanied with epithelial‐to‐mesenchymal tra
The p53 homologue p63 is essential for ectodermal differentiation, such that p63؊/؊ mice lack all squamous epithelia and teeth. The p63 gene expresses at least 6 different transcripts, but information regarding the expression, regulation and function of the different isoforms has remained sparse, du