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90 CD25 expression distinguishes functionally distinct alloreactive CD4+CD134+ T cell subsets in acute GVHD

✍ Scribed by R.T. Maziarz; X. Zhang; P.R. Streeter


Book ID
117728097
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
135 KB
Volume
9
Category
Article
ISSN
1083-8791

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## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut