9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-β but no change in cyclooxygenase-2

Inhibition of lung carcinogenesis by 1α,

Inhibition of lung carcinogenesis by 1α,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: Evidence of retinoid mitigation of vitamin D toxicity

✍ Heather Mernitz; Donald E. Smith; Richard J. Wood; Robert M. Russell; Xiang-Dong 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 334 KB

## Abstract 9__‐cis__‐Retinoic acid (9cRA) and 1α,25‐dihydroxyvitamin D~3~ (1,25D) show promise as potential chemopreventive agents. We examined 9cRA and 1,25D, alone and in combination, for their potential to inhibit carcinogen (NNK)‐induced lung carcinogenesis in A/J mice. A/J mice (__n__ = 14/gr