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9-cis Retinoic acid induces the expression of the uncoupling protein-2 gene in brown adipocytes

✍ Scribed by M.C Carmona; A Valmaseda; R Iglesias; T Mampel; O Viñas; M Giralt; F Villarroya


Book ID
117110204
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
115 KB
Volume
441
Category
Article
ISSN
0014-5793

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Fetal brown adipocytes expressed uncoupling protein 1 (UCP1) mRNA, this expression being blunted throughout culture for 24 h in a serum-free medium. At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1