9-Cis-retinoic acid exhibits antifibrotic activity via the induction of cyclooxygenase-2 expression and prostaglandin E2 production in scleroderma fibroblasts

Hyaluronic acid inhibits mRNA expression

Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E2 production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease

✍ Yasuhiro Mitsui; Masafumi Gotoh; Kenjirou Nakama; Tetsu Yamada; Fujio Higuchi; K 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 332 KB

## Abstract A growing body of evidence supports use of intraarticular hyaluronic acid (HA) injection in patients with rotator cuff disease. However, the mechanism of its anti‐inflammatory action has not been clarified. We examined the effects of HA on the expression of mRNAs for proinflammatory cyt