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883 POSTER Phase I trial of sorafenib (BAY 43–9006) in combination with interferon alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma and malignant melanoma


Book ID
118623459
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
140 KB
Volume
3
Category
Article
ISSN
1359-6349

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Preclinical data suggest synergy of interleukin-2 (IL-2) combined with alphainterferon (IFN). In addition, toxicities of IL-2 may be decreased by intermittent continuous infusion. The purpose of this trial was to determine the maximum tolerated dose (MTD) of recombinant IL-2 combined with alpha-IFN