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8.7-01 Correlation between binding of cyclosporine metabolites to peripheral blood mononuclear cells and immunosuppression in vitro

✍ Scribed by McKenna, R.M; Copeland, K; Rush, D; Jeffrey, J; Yatscoff, R


Book ID
123213749
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
98 KB
Volume
26
Category
Article
ISSN
0198-8859

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Correlation of cyclosporine and metaboli
✍ James G. Donnelly; Rosalind L. Russell; Edmund W. Palaszynski; Kenneth R. Copela πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 366 KB

Seven purified cyclosporine (CsA) metabolites were analyzed for binding to cyciophilin and to a 50 kDa protein purified from a JURKAT cell line. In addition, the potency of the seven metabolites, relative to CsA, was obtained using a primary mixed lymphocyte culture (MLC) suppression assay. CsA, M1,