Correlation of cyclosporine and metaboli
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James G. Donnelly; Rosalind L. Russell; Edmund W. Palaszynski; Kenneth R. Copela
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Article
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1991
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Elsevier Science
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English
β 366 KB
Seven purified cyclosporine (CsA) metabolites were analyzed for binding to cyciophilin and to a 50 kDa protein purified from a JURKAT cell line. In addition, the potency of the seven metabolites, relative to CsA, was obtained using a primary mixed lymphocyte culture (MLC) suppression assay. CsA, M1,