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86Rb+ fluxes in Chinese hamster ovary cells as a function of membrane cholesterol content

โœ Scribed by Tilly Bakker-Grunwald; Michael Sinensky


Book ID
115724286
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
612 KB
Volume
558
Category
Article
ISSN
0005-2736

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Methotrexate (MTX) covalently linked to poly(L-lysine) [poly(Lys)] enters cells by endocytosis, is degraded in lysosomes and, upon liberation of small molecular methotrexate, is cytocidal to Chinese hamster cells in culture. This drug conjugate was used to select mutants resistant to MTX-poly(Lys),