The RAS/MAPK syndromes: novel roles of t
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Yoko Aoki; Tetsuya Niihori; Yoko Narumi; Shigeo Kure; Yoichi Matsubara
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Article
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2008
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John Wiley and Sons
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English
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The RAS proteins and their downstream pathways play pivotal roles in cell proliferation, differentiation, survival and cell death, but their physiological roles in human development had remained unknown. Noonan syndrome, Costello syndrome, and cardio-facio-cutaneous (CFC) syndrome are autosomal domi