86 INVITED Novel Designs and Alternate Endpoints for New Drug Studies
β Scribed by C. Dittrich
- Book ID
- 117660797
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 54 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0959-8049
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of the guanine nucleoside. Modification of the ester an