854 REGULATION OF HEPATITIS C VIRUS REPLICATION BY NUCLEAR TRANSLOCATION OF NONSTRUCTURAL 5A PROTEIN AND TRANSCRIPTIONAL ACTIVATION OF HOST GENES
โ Scribed by M.A. Maqbool; M. Higgs; J.-M. Pawlotsky; H. Lerat
- Book ID
- 117381062
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 58 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0168-8278
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The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina