849 The role of CHEK2 and MSR1 genes in prostate cancer predisposition in Finland
✍ Scribed by M. Matikainen; E. Seppälä; T. Ikonen; V. Autio; N. Mononen; A. Rökman; T. Tammela; J. Schleutker
- Book ID
- 118646050
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 205 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1569-9056
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The MSR1 gene at 8p22 has been suggested as a candidate gene for hereditary prostate cancer because germline variants have been found to be associated with the disease. Aside from a single nonsense mutation (R293X) that was found repeatedly at low frequencies in several samples, little evidence has
## Abstract Three putative prostate cancer–susceptibility genes, __RNASEL/HPC1__ at 1q24, __MSR1__ at 8p22, and __ELAC2/HPC2__ at 17p11, have recently been identified. Our objective was to investigate somatic mutations in these genes in sporadic prostate cancer. We analyzed 39 clinical prostate can