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849 A Long-Term, Mesenchyme-Free In Vitro Culture System of Colonic Epithelial Cells Retaining Stem Cell Compartment With Proliferation/Differentiation Properties

✍ Scribed by Shiro Yui; Tetsuya Nakamura; Tomohiro Mizutani; Yasuhiro Nemoto; Ryuichi Okamoto; Kiichiro Tsuchiya; Shizuko Ichinose; Mamoru Watanabe

Book ID: 119431382
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 54 KB
Volume: 138
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(10)60532-x

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## Abstract Human bone marrow mesenchymal stem cells (hMSCs) are promising candidates for cell therapy and tissue engineering. The life span of hMSCs during in vitro culture is limited. Human telomerase catalytic subunit (hTERT) gene transduction can prolong the life span of hMSCs and maintain thei