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844 The Changes in MGMT Promoter Methylation Status in Primary and Recurrent Glioblastomas

✍ Scribed by C. Park; J.E. Kim; S. Lee; T. Kim; S. Park


Book ID
117663310
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
52 KB
Volume
48
Category
Article
ISSN
0959-8049

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## Abstract Epigenetic silencing of the O^6^‐methylguanine‐DNA methyltransferase (__MGMT__) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methyl