82Br-bromphenol blue: A potential hepatobiliary imaging agent. Organ distribution and biliary excretion in the rat

Biliary excretion and pharmacokinetics o

Biliary excretion and pharmacokinetics of a gadolinium chelate used as a liver-specific contrast agent for magnetic resonance imaging in the rat

✍ Gabriele Schuhmann-Giampieri; Heribert Schitt-Willich; Thomas Frenzel 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 735 KB

The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a magnetic resonance contrast agent for liver mass screening. The pharmacokinetics of Gd-EOB-DTPA in rats is nonlinear because a