817 Integration of gene and miRNA expression profiles in clear cell renal carcinoma cell lines and relationship with VHL gene status
β Scribed by C. Battaglia; V. Tinaglia; I. Cifola; F. Frascati; E. Mangano; M. Biasolo; S. Bortoluzzi; S. Bombelli; C. Bianchi; R. Perego
- Book ID
- 119602593
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 52 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-6349
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## Abstract We attempted to describe, in a series of clear cell renal cell carcinoma (RCC), the relationship between CAIX expression, VHL gene mutations, tumor characteristics and outcome. Radical nephrectomy was performed in 100 patients. Genomic DNA was extracted from frozen tumor samples. Four a
## Abstract To delineate more precisely the somatic von HippelβLindau disease (VHL) gene alteration as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 sporadic renal cell carcinomas (RCCs) for somatic __VHL__ gene alterations by DNAβSSCP followed by sequen