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810 Simvastatin Inhibits Leptin-activated Signaling Pathways That Promote Migration and Invasiveness of Ovarian Cancer Cells

✍ Scribed by M. Cuello-Fredes; S. Kato; D. Diaz; A. Vecchiola; J. Branes; M.I. Barriga; R. Gejman; G.I. Owen


Book ID
117663276
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
71 KB
Volume
48
Category
Article
ISSN
0959-8049

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## Abstract Leptin serum levels are about 5 times higher in obese people than in normal individuals. We aimed at investigating the signaling pathways induced by leptin in the human colonic cell lines LS174T and HM7. Both cells expressed the leptin transmembrane Ob‐receptor. Leptin activated the mit