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8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities

✍ Scribed by Shimada, Junichi; Suzuki, Fumio; Nonaka, Hiromi; Karasawa, Akira; Mizumoto, Hideaki; Ohno, Tetsuji; Kubo, Kazuhiro; Ishii, Akio


Book ID
126793456
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
514 KB
Volume
34
Category
Article
ISSN
0022-2623

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The reduction of 1-allyl-8-cyclopentyl-3-(3-fluoropropyl)xanthine, 7, with tritium gas catalyzed by 10% Pd-C gave 8-cyclopentyl-3-(3-fluoropropyl)-1-[2,3-3 H]propylxanthine ([ 3 H]CPFPX), 8\*, a potent and selective antagonist for the A 1 adenosine receptor (A 1 AR). The synthesis of 7 proceeded fro