✦ LIBER ✦

8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes†

✍ Scribed by Eckhardt, Matthias; Langkopf, Elke; Mark, Michael; Tadayyon, Moh; Thomas, Leo; Nar, Herbert; Pfrengle, Waldemar; Guth, Brian; Lotz, Ralf; Sieger, Peter

Book ID: 111651459
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 235 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm701280z

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-y

(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors

✍ Thomas, L.; Eckhardt, M.; Langkopf, E.; Tadayyon, M.; Himmelsbach, F.; Mark, M. 📂 Article 📅 2008 🏛 American Society for Pharmacology and Experimental 🌐 English ⚖ 644 KB

(2 R )-4-Oxo-4-[3-(Trifluoromethyl)-5,6-

(2 R )-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3- a ]pyrazin- 7(8 H )-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

✍ Kim, Dooseop; Wang, Liping; Beconi, Maria; Eiermann, George J.; Fisher, Michael 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 327 KB

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluor

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6- [2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl- [1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-on# e (I) (BMS-740808) a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.

✍ Donald J. P. Pinto; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 10 KB 👁 1 views

Discovery of ((4 R ,5 S )-5-Amino-4-(2,4

Discovery of ((4 R ,5 S )-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8 H )-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

✍ Pei, Zhonghua; Li, Xiaofeng; von Geldern, Thomas W.; Madar, David J.; Longenecke 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 190 KB