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7,8-Dihydro-5(6H)quinolones. Potential intermediates for the synthesis of pumiliotoxic C

✍ Scribed by Gregory B. Bennett; Harold Minor


Book ID
112125659
Publisher
Journal of Heterocyclic Chemistry
Year
1979
Tongue
English
Weight
224 KB
Volume
16
Category
Article
ISSN
0022-152X

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We have developed an efficient and convenient strategy for the regioselective synthesis of new conformationally restricted butyrophenones of the quinoline series. The 7-aminomethyl-7,8-dihydro-6Hquinolin-5-ones 9 were obtained from protected alcohol 5 via the tosylate, and also in a one-pot reaction