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774 - Expression of r-glutamylcysteine gene in human urothelial cancer: Relation to chemotherapy response

✍ Scribed by Chi-Rei Yang; Yen-Chuan Ou; Jehn-Hwa Kuo; Yu-Lin Kao; Chen-Li Cheng; Sheau-Yun Yean; Yu-Ye Homg


Book ID
117665019
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
249 KB
Volume
33
Category
Article
ISSN
0959-8049

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Glutathione (β₯-glutamylcysteinyl glycine, GSH) is believed to be important in the acquisition of resistance to anti-cancer drugs such as cisplatin (CDDP) and doxorubicin (DOX). β₯-Glutamylcysteine synthetase (β₯-GCS) is a key enzyme for maintaining intracellular GSH levels; it is composed of a catalyt