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765 Sprouty-2 Is Up-Regulated in Human Colon Cancers and Functions As An Oncogene: Role of C-MET

โœ Scribed by Cory Holgren; Urszula Dougherty; Francis Edwin; Dario Cerasi; Ieva Taylor; Alessandro Fichera; Marc Bissonnette; Sharad Khare


Book ID
119430392
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
178 KB
Volume
136
Category
Article
ISSN
0016-5085

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Synergistic role of sprouty2 inactivatio
โœ Susie A. Lee; Sara Ladu; Matthias Evert; Frank Dombrowski; Valentina De Murtas; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 875 KB

Sprouty2 (Spry2), a negative feedback regulator of the Ras/mitogen-activated protein kinase (MAPK) pathway, is frequently down-regulated in human hepatocellular carcinoma (HCC). We tested the hypothesis that loss of Spry2 cooperates with unconstrained activation of the c-Met protooncogene to induce