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76 Altered Food Consumption Contributes to Obesity Protection and Reversal in Mice Lacking Liver Fatty Acid Binding Protein

✍ Scribed by Newberry, Elizabeth P.; Kennedy, Susan; Luo, Jianyang; Crooke, Roeaanne M.; Graham, Mark J.; Davidson, Nicholas O.


Book ID
122672633
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
83 KB
Volume
138
Category
Article
ISSN
0016-5085

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✍ Elizabeth P. Newberry; Yan Xie; Susan M. Kennedy; Jianyang Luo; Nicholas O. Davi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 713 KB

Liver fatty acid-binding protein (L-Fabp) regulates murine hepatic fatty acid trafficking in response to fasting. In this study, we show that L-Fabp(-/-) mice fed a high-fat Western diet for up to 18 weeks are less obese and accumulate less hepatic triglyceride than C57BL/6J controls. Paradoxically,