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759 - Phase II study of 24 hours-infusion of 5-fluorouracil and high dose folinic acid in patients with progressive or recurrent colorectal cancer (CRC)

✍ Scribed by J.T. Hartmann; C.H. Köhne; H.-J. Schmoll; C. Kollmannsberger; L. Kanz; C Bokemeyer


Book ID
117665005
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
269 KB
Volume
33
Category
Article
ISSN
0959-8049

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✍ Dennie V. Jones; Roger J. Winn; Barry W. Brown; Lawrence B. Levy; Reginald P. Pu 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 501 KB

Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized