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75-kd sirtuin 1 blocks tumor necrosis factor α–mediated apoptosis in human osteoarthritic chondrocytes

✍ Scribed by Hanna Oppenheimer; Odile Gabay; Hadar Meir; Amir Haze; Leonid Kandel; Meir Liebergall; Viktoria Gagarina; Eun Jin Lee; Mona Dvir-Ginzberg

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
477 KB
Volume
64
Category
Article
ISSN
0004-3591

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Tumor necrosis factor α–mediated cleavag
Tumor necrosis factor α–mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
✍ Mona Dvir-Ginzberg; Viktoria Gagarina; Eun Jin Lee; Richard Booth; Odile Gabay; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB

## Abstract ## Objective The protein deacetylase SirT1 positively regulates cartilage‐specific gene expression, while the proinflammatory cytokine tumor necrosis factor α (TNFα) negatively regulates these same genes. This study was undertaken to test the hypothesis that SirT1 is adversely affected