722Blockade of VEGF-R and EGF-R signalling reduces growth and metastasis of human prostate cancer in an orthotopic nude mouse model
β Scribed by Yazici M.S.; Busby E.; Fidler I.J.; Kim S.J.
- Book ID
- 118646851
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 190 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1569-9056
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We established an orthotopic treatment model of prostate cancer to generate reproducible primary and metastatic carcinoma in immunocompetent C57BL/6 mice. Using an __in vivo__ selection scheme of intraprostatic implantation of TRAMPβC1 cells, primary prostate tumors were cultured and re
## Abstract Metastasis to the bone is a major clinical complication in patients with prostate cancer (PC). However, therapeutic options for treatment of PC bone metastasis are limited. Gelatinases are members of the matrix metalloproteinase (MMP) family and have been shown to play a key role in PC