719 Protection by tetrahydrobiopterin from nitric oxide-induced neuronal cell death
โ Scribed by Kunio Koshimura; Junko Tanaka; Yoshio Murakami; Yuzuru Kato
- Book ID
- 119130274
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 96 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0168-0102
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Neuronal injury is intricately linked to the activation of three distinct neuronal endonucleases. Since these endonucleases are exquisitely pH dependent, we investigated in primary rat hippocampal neurons the role of intracellular pH (pH i ) regulation during nitric oxide (NO)-induced toxicity. Neur
Nitric oxide (NO) has cytotoxic effects but NO producing neurons are resistant to NO toxicity. These results suggest the presence of self-protecting factors for NO toxicity. Recently, 6R-tetrahydrobiopterin (6R-BH 4 ), a cofactor for NO synthase (NOS), has been reported to degrade NO raising the pos
Previously we reported that the synthesis of catecholamines, dopamine, and noradrenaline was enhanced by overexpression of V-1 protein, a neuronal protein active in the initial stage of development of the rat cerebellum, in the neuronal cell line PC12D, a model of dopamine cells (Yamakuni et al. [19
Oxidative stress is important in the process of dopaminergic neuronal degeneration in Parkinson's disease. Recent studies suggest that estrogens have neuroprotective effects in neurodegenerative disorders, including Alzheimer's disease. In the present study, we investigated neuroprotection against o