713-6 Functional and Metabolic Protection of the Ischemic Rabbit Heart by NO Synthase Inhibitor

Cardioprotection with pioglitazone is ab

Cardioprotection with pioglitazone is abolished by nitric oxide synthase inhibitor in ischemic rabbit hearts–comparison of the effects of pioglitazone and metformin

✍ Hitoshi Kawabata; Kinji Ishikawa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB

## Abstract ## Background The effects of two drugs representing different classes of antidiabetic pharmacology (pioglitazone, a thiazolidinedione; and metformin, a biguanide) on the myocardial metabolism in the ischemia are poorly understood. ## Methods To test the hypothesis that cardioprotecti