In vivo efficacy of STI571 in xenografte
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Didier Decaudin; Patricia de Cremoux; Xavier Sastre; Jean-Gabriel Judde; Fariba
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Article
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2004
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John Wiley and Sons
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French
⚖ 227 KB
## Abstract STI571, or imatinib, selectively inhibits BCR/ABL, PDGFR and c‐kit kinase activity. It has been reported that a large proportion of small cell lung cancer (SCLC) cell lines and tumors express c‐kit and that STI571 inhibits tumor cell growth. We therefore investigated the therapeutic eff