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71 In vivo efficacy of STI571 in xenografted human small cell cancer alone or combined with chemotherapy

✍ Scribed by D. Decaudin; P. de Cremoux; X. Sastre; F. Némati; C. Tran-Perennou; P. Fréneaux; A. Livartowski; P. Pouillart; M.F. Poupon


Book ID
118621255
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
143 KB
Volume
2
Category
Article
ISSN
1359-6349

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In vivo efficacy of STI571 in xenografte
✍ Didier Decaudin; Patricia de Cremoux; Xavier Sastre; Jean-Gabriel Judde; Fariba 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 227 KB

## Abstract STI571, or imatinib, selectively inhibits BCR/ABL, PDGFR and c‐kit kinase activity. It has been reported that a large proportion of small cell lung cancer (SCLC) cell lines and tumors express c‐kit and that STI571 inhibits tumor cell growth. We therefore investigated the therapeutic eff