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706 In vitro and in vivo efficacy of a HIF-1alpha-antisense oligonucleotide containing locked nucleic acids

✍ Scribed by A. Hoeg; C. Thrue; H. Oerum; P. Kristjansen


Book ID
118620878
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
334 KB
Volume
1
Category
Article
ISSN
1359-6349

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## Abstract The expression of MRP1 (multidrug resistance protein‐1) is associated with chemoresistance and poor prognosis in neuroblastoma. MRP1 antisense oligonucleotides were used in an __in vivo__ mouse‐human xenograft model of neuroblastoma to downregulate MRP1. The MRP1 ASO reduced protein lev