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704: Phenotype based discovery of novel small molecule anti-angiogenic drugs

✍ Scribed by Butler, C.


Book ID
125800179
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
66 KB
Volume
50
Category
Article
ISSN
0959-8049

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Identification of a novel small molecule
✍ Hye Jin Jung; Ki Hyun Kim; Nam Doo Kim; Gyoonhee Han; Ho Jeong Kwon πŸ“‚ Article πŸ“… 2011 πŸ› Elsevier Science 🌐 English βš– 836 KB

Our recent study has shown that ubiquinol-cytochrome c reductase binding protein (UQCRB), the 13.4-kDa subunit of mitochondrial complex III, plays a crucial role in hypoxia-induced angiogenesis via mitochondrial reactive oxygen species (ROS)-mediated signaling. Here we report a new synthetic small m